Although both are forms of vitamin B9. The key difference lies in bioavailability: active folic acid (5-MTHF) is ready to be used by the body, while synthetic folic acid requires hepatic conversion.

Folic Acid (Synthetic): It is the synthetic form used in supplements and fortified foods. It is not active by itself; the body must convert it in the liver into active folate to be able to use it.

Active Folate/Methylfolate (5-MTHF): It is the active form of vitamin B9. It is absorbed immediately and does not need conversion. It is ideal for people with genetic mutations (MTHF gene) that limit the conversion of common folic acid. It is estimated that this polymorphism is possessed by more than 40% of the population.

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Natural Folate: It is the vitamin B9 naturally present in foods (leafy green vegetables, citrus fruits, legumes).

Bioavailability: Active folate has greater bioavailability and efficacy in the body than conventional folic acid.

In summary, active folate is a more advanced, safer, and more easily absorbable form than traditional synthetic folic acid.